1. Introduction. - 2. Fundamentals of Biochemical Modeling. - 2. 1. Balance Equations. - 2. 2. Rate Laws. - 2. 3. Steady States of Biochemical Networks. - 2. 4. Metabolic Oscillations. - 3. Stoichiometric Analysis. - 3. 1. Conservation Relations. - 3. 2. Admissible Steady-State Vectors and the Null-Space. - 3. 3. Thermodynamic Aspects. - 4. Time Hierarchy in Metabolism. - 4. 1. Time Constants of Metabolic Processes. - 4. 2. The Quasi-Steady-State Approximation. - 4. 3. The Rapid-Equilibrium Approximation. - 4. 4. Modal Analysis. - 5. Metabolic Control Analysis. - 5. 1. Basic Definitions. - 5. 2. A Systematic Approach. - 5. 3. Theorems of Metabolic Control Analysis. - 5. 4. Control Analysis of Various Systems. - 5. 5. Time-Dependent Control Coefficients. - 5. 6. Are Control Coefficients Always Parameter Independent?. - 5. 7. Normalized Versus Non-normalized Coefficients. - 5. 8. Analysis in Terms of Variables Other Than Concentrations and Fluxes. - 5. 9. A Second-Order Approach. - 5. 10. Metabolic Regulation from the Viewpoint of Control Analysis. - 5. 11. Control Within and Between Subsystems. - 5. 12. Modular Approach. - 5. 13. Flux Control Insusceptibility. - 5. 14. Control Exerted by Elementary Steps in Enzyme Catalysis. - 5. 15. Control Analysis of Metabolic Channeling. - 5. 16. Comparison of Metabolic Control Analysis and Power- Law Formalism. - 5. 17. Computational Aspects. - 6. Application of Optimization Methods and the Interrelation with Evolution. - 6. 1. Optimization of the Catalytic Properties of Single Enzymes. - 6. 2. Optimization of Multienzyme Systems. - 6. 3. Optimal Stoichiometrics. - References. Language: English