Mutation research

1 The history of mutation research. - 2 Classification of mutational changes at the chromosomal level. - 3 Classification of gene mutations. - 4 Reverse mutations. Suppressors. - 5 The classical X-ray work. I: Mutations. The target theory. - 6 The classical X-ray work II: Chromosome breaks and rearrangements. Do X-rays produce true gene mutations?. - 7 Direct and indirect action of X-rays. Radio-isotopes. Radiation-sterilized food. - 8 Repair of X-ray damage I: Repair of chromosome breaks. - 9 Repair of X-ray damage II: Repair of mutagenic lesions. Molecular action of X-rays. Sensitivity differences. - 10 Mutagenesis by ultraviolet and visible light I: Early work on macro-organisms. - 11 Mutagenesis by ultraviolet and visible light II: Methods of mutation research on microorganisms and mammalian cell cultures. - 12 Mutagenesis by ultraviolet and visible light II: Early work on micro-organisms. - 13 The molecular action of ultraviolet and visible light I: Photoproducts. Photorepair. - 14 The molecular action of ultraviolet and visible light II: Dark repair. Mechanisms of mutation induction. - 15 Chemical mutagens: alkylating agents. I: Genetical effects. - 16 Chemical mutagens: alkylating agents. II: Chemistry. Molecular analysis of mutants. Influence of cellular processes. Kinetics. - 17 Chemical mutagens: purines; base analogues; acridines; hydroxylamine; hydrazine; bisulphite. Reversions analysis. - 18 Nitrous acid. Other chemical mutagens. - 19 The relation between induced crossovers rearrangements and mutations. The origin of complete (non-mosaic) mutations. - 20 Mutagen specificity. - 21 Spontaneous mutations. - 22 Instabilities. - 23 Applied mutation research. - Author Index. Language: English